Scientific News

Therapeutic plasma exchange in Amatoxin-associated paediatric acute liver failure—results from the Amanita-PEX study

The retrospective multicentre Amanita-PEX study examined outcomes and the role of therapeutic plasma exchange in children with amatoxin-associated acute liver failure.

Amplification of genetic and metabolic factors in alpha-1 antitrypsin deficiency

A study links obesity and diabetes to worse liver outcomes in adults with Pi*ZZ alpha-1 antitrypsin deficiency, highlighting the combined impact of genetic and metabolic risk factors.

Crisis Readiness for Rare Disease Populations: Lessons from the European Reference Networks

A study across all 24 ERNs identifies gaps in emergency preparedness and proposes a 10-point plan to maintain rare disease care during crises.

Patient pathways for rare liver diseases: a European template developed by ERN RARE-LIVER

ERN RARE-LIVER has developed a European framework for patient-centred pathways, translating clinical recommendations and patient priorities into coordinated care.

Study: Complementary use of autoantibody detection methods in diagnosis of juvenile AIH and ASC

Can we diagnose paediatric autoimmune liver disease faster and more reliably? A new European multicentre study specifically addresses this question.

EASL Clinical Practice Guidelines on vascular diseases of the liver

A new 2025 EASL guideline outlines expert recommendations for the diagnosis and management of major vascular liver diseases, emphasising early detection, stepwise treatment strategies, and multidisciplinary care.

Medical Management of Polycystic Liver Disease: A Position Statement From the European Reference Network on Hepatological Diseases

A new ERN RARE-LIVER position paper presents expert consensus on the use of somatostatin analogues in the management of polycystic liver disease.

Therapeutic plasma exchange in amatoxin associated acute liver failure-results from the multi-center Amanita-PEX study

A multicentre study analyzed patients with amatoxin-induced acute liver failure from 25 centers between 2013 and 2024, comparing therapeutic plasma exchange with standard-of-care treatment.

Trends in Primary Biliary Cholangitis: Prospective Cohort Study From the European Reference Network Registry (R-LIVER)

Real-world data from the ERN RARE LIVER registry highlight current practices in PBC management and reveal opportunities to optimise care for higher-risk patients.