Clinical practice guidelines and position papers

One of the tasks set by the European Commission for the ERNs is to contribute towards advancing clinical care in rare liver diseases by developing practice guidelines and position papers. We are pleased to collaborate with EASL and ESPGHAN in this regard to ensure that our activities are mutually beneficial and that we share knowledge and experience in the most effective way.

Please find below a list of guidelines and position papers endorsed by ERN RARE-LIVER:


Acute Liver Failure 

Alpha-1 antitrypsin deficiency (AATD

Autoimmune Hepatitis (AIH

Cystic Liver Diseases 

  • EASL Guideline, 2022
    (Including hepatic cysts, mucinous cystic neoplasms of the liver, biliary hamartomas, polycystic liver disease, Caroli disease, Caroli syndrome and peribiliary cysts) 

Genetic Cholestatic Diseases 


Intrahepatic Cholangiocarcinoma 

Intrahepatic cholestasis of pregnancy; HELLP syndrome 

Primary Biliary Cholangitis (PBC

Sclerosing Cholangitis

Vascular Liver Diseases 

Wilson Disease 

Liver Disease in Pregnancy 

Liver Transplantation

Transition from paediatric to adult care 

EASL Quiz -
Test Your Guidelines Knowledge

Test your Guidelines Knowledge – quick, handy, and helpful – to sharpen your skills. Each quiz presents a short case, drawing from EASL’s Clinical Practice Guidelines and relating to the latest in diagnostic and therapeutic developments. It poses a question and offers 4-5 possible answers to choose from. Pick your answer, check if it’s right, and compare with your peers’ responses. 

>> Click here <<

The presented methodology is based on the current international “gold standards” that have been developed along the years and used by key international and national bodies and organisations specialised in the development of Clinical Practice Guidelines and other Clinical Decision Support Tools. 

This methodology will ensure the quality and standardisation of the CPG and CDST produced and used by the ERNs, the backbone of the process of the diagnosis and treatment of patients suffering of rare or low prevalence and complex diseases. 

The handbook includes 12 separated guidelines addressing the following conceptual and methodological aspects of the programme. 

  1. Introduction to the handbook
  2. Prioritisation
  3. Appraisal
  4. Adaptation & Adoption
  5. Elaboration of CPG
  6. Elaboration of Clinical Consensus Statements
  7. Elaboration of Evidence Reports
  8. Elaboration of Pathways
  9. Elaboration of Evidence Based Protocols
  10. Elaboration of Do’s & Don’ts Factsheets
  11. Elaboration of Quality Measures
  12. Elaboration of Patient Information Booklets
  13. Evaluation of Uptake of CPGs and CDST