Clinical practice guidelines and position papers
One of the tasks set by the European Commission for the ERNs is to contribute towards advancing clinical care in rare liver diseases by developing practice guidelines and position papers. We are pleased to collaborate with EASL and ESPGHAN in this regard to ensure that our activities are mutually beneficial and that we share knowledge and experience in the most effective way.
Please find below a list of guidelines and position papers endorsed by ERN RARE-LIVER:
Acute Liver Failure
Alpha-1 antitrypsin deficiency (AATD)
Autoimmune Hepatitis (AIH)
- EASL Guideline, 2025
- ERN RARE-LIVER and IAIHG Position paper, 2020: Second-line and third-line therapy for autoimmune hepatitis
- ESPGHAN Guideline for paediatric patients, 2019
- EASL Guideline, 2015
Cystic Liver Diseases
- EASL Guideline, 2022
(Including hepatic cysts, mucinous cystic neoplasms of the liver, biliary hamartomas, polycystic liver disease, Caroli disease, Caroli syndrome and peribiliary cysts)
Genetic Cholestatic Diseases
- EASL Guideline, 2025
- NASPGHAN and ESPGHAN Guideline on Cholestatic Jaundice in Infants, 2017
- EASL Guideline on cholestatic-liver-diseases, 2009
Haemochromatosis
Intrahepatic Cholangiocarcinoma
Intrahepatic cholestasis of pregnancy; HELLP syndrome
Primary Biliary Cholangitis (PBC)
Sclerosing Cholangitis
- EASL Guideline on Sclerosing Cholangitis, 2022
(Including primary and secondary sclerosing cholangitis) - ESGE and EASL Guideline, 2017
- EASL Guideline on cholestatic-liver-diseases, 2009
Vascular Liver Diseases
- EASL Guideline, 2025
- ERN RARE-LIVER Position paper, Expert management of congenital portosystemic shunts and their complications , 2023
- AASLD Practice Guidance, 2020
(Including Vascular Liver Disorders, Portal Vein Thrombosis, and Procedural Bleeding in Patients With Liver Disease) - AFEF and ERN RARE-LIVER Position papers, 2020
- EASL Guideline, 2015
Wilson Disease
Liver Disease in Pregnancy
Liver Transplantation
- EASL Guideline, 2025
- ESPGHAN Guideline on LTX for paediatric Autoimmune Liver Diseases, 2019
- EASL Guideline, 2015