Therapeutic plasma exchange in amatoxin associated acute liver failure-results from the multi-center Amanita-PEX study

A multicentre study analyzed patients with amatoxin-induced acute liver failure from 25 centers between 2013 and 2024, comparing therapeutic plasma exchange with standard-of-care treatment.

Back to overview

Amatoxin (AT), found in Amanita phalloides (death cap) mushrooms, causes acute liver failure (ACLF) with a high mortality without liver transplantation (LTX). In other cases of ALF, there are indications that therapeutic plasma exchange (PEX) might enhance LTX-free survival. This retrospective multicenter study analyzed patients with AT-ALF from 2013 – 2024 from 25 centers and compared PEX and standard-of-care treatment. Under real-world conditions, this study shows that patients treated with PEX showed higher rates of hepatic encephalopathy ≥ 2 but also showed higher rates of 28-day LTX-free survival.

The full publication is available here.