Prognostic value of liver stiffness measurement vs. biochemical response in primary biliary cholangitis

A new multicentre study evaluates the prognostic value of liver stiffness measurement in PBC, highlighting its role in predicting hepatic decompensation independently of biochemical response.

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In primary biliary cholangitis (PBS), both liver stiffness measurement (LSM) and the biochemical response are frequently used parameters in treatment monitoring, but they also carry prognostic value. The discordance between LSM and the biochemical response poses a frequently arising prognostic dilemma. Hence this retrospective, multicentre study (n = 1,793) investigated the performance of LSM in predicticting first hepatic decompensation in this setting. The study found that an LSM >10 kPa strongly predicted hepatic decompensation irrespective of biochemical response and prior LSM trajectories.

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