As a result, comprehensive clinical guidance on the subject matter is warranted. These Clinical Practice Guidelines (CPGs) by the European Association for the Study of the Liver were commissioned to provide guidance on the clinical management of non-infectious cystic liver diseases. These lesions encompass simple hepatic cysts, mucinous cystic neoplasms of the liver, polycystic liver disease, Caroli disease, Caroli syndrome, biliary hamartomas and peribiliary cysts. The disorders de-scribed in these CPGs are broadly termed fibrocystic diseases. On the basis of in-depth review of the relevant literature we provide recommendations to navigate clinical dilemmas followed by supporting text. We aim to provide the best available evidence to aid the clinical decision-making process in the management of patients with cystic liver disease.