AOU Federico II di Napoli



Contact Information for physicians and patients

Azienda Ospedaliera Universitaria Federico II
Via S.Pansini, 5
80131 Napoli

Particular rare liver disease expertise of the centre

A Wilson Team is available to manage patients with Wilson’s Disease. It allows to the Centre to take care of hepatic, neurological, psychiatric, gynecological, ophthalmological, and childhood neuropsychiatric conditions in patients with Wilson’s Disease. In addition, the team includes two expert radiologists in liver US and brain MRI and efficient laboratory for copper serum and urine levels and for genetic diagnosis of Wilson’s Disease. The centre also has more than 30 years of experience in the diagnosis and treatment of neonatal cholestasis on a genetic and non-genetic basis. Infants with cholestasis are referred from other hospitals of the region for the appropriate investigations including genetic panel for neonatal cholestasis available in situ (CE.IN.GE.). Furthermore, the center has extensive experience in the diagnosis and management of biliary atresia (including pre-transplant follow-up, nutritional care, and long-term surveillance of liver function and complications in children surviving with native liver), Alagille syndrome, Autoimmune Hepatitis and cholangitis, primary sclerosing cholangitis, non-cirrhotic portal vein thrombosis.

ERN Representatives

  • di_dato_1.jpg

    Dr. Fabiola Di Dato

    Pediatrician, PhD student

  • iorio_1_1_.jpg

    Prof. Raffaele Iorio

    Associate Professor of Pediatrics

ERN Team and Contact

  • Pediatric Hepatologists: Prof. Raffaele Iorio, Dr. Fabiola Di Dato
  • Adult Hepatologists: Dr. Margherita Matarazzo, Prof. Filomena Morisco 
  • Pediatric Clinical Nutrition: Prof. Maria Immacolata Spagnuolo 
  • Clinical Biochemistry and Clinical Molecular Biology: Dr. Marcella Savoia, Prof. Giuliana Fortunato
  • Interventional Radiologists: Dr. Pietro Venetucci, Dr. Mario Quarantelli
  • Radiologists: Dr. Fabio Tortora, Dr. Sirio Cocozza, Dr. Emilia Vergara
  • Pathologist: Prof. Maria Rosaria D’Armiento 
  • Neurologists (Wilson’s disease): Dr. Anna De Rosa, Dr. Gaetano Terrone


  • riorio(at)
  • fabiola.didato(at)
  • wilsonfederico(at) (Wilson’s Disease dedicated mailbox)

Centre information

The Pediatric Liver Unit of Federico II University Hospital (Azienda Ospedaliera Universitaria AOU Federico II) of Naples provides a comprehensive approach to the care of patients with rare liver disease through the work of a multidisciplinary team that includes pediatric hepatologists and gastroenterologists, experts in pediatric subspecialties (clinical nutrition, neurology, genetics), and adult hepatologists interested in the transition from pediatric to adult care. Furthermore, there is a close collaboration with pediatric surgeons, pediatric dieticians, radiologists, psychologists, pediatric gynecologists. The centre has developed clinical and scientific expertise in the field of liver disease over the past 35 years. In particular, there is a great experience in the diagnosis, therapy and management of Wilson’s disease patients. AOU Federico II manages patients with Wilson’s disease from many Italian regions. In addition to clinical care, the members of this team are involved in clinical and translational research and education with national and international collabortions. The specialists of the team are members of Italian and/or European scientific societies (ESPGHAN, SIGENP, AISF), with active participation in the programs of these societies. They contributed significantly to the clinical guidelines for Pediatric Wilson’s Disease of the European Society of Pediatric Gastroenterolgy, Hepatology and Nutrition (ESPGHAN) and for neonatal cholestasis and acute liver failure of Italian Society of Pediatric Gastroenterolgy, Hepatology and Nutrition (SIGENP). They are also in close contact with associations of patients. The AOU Federico II center is actively involved in screening programs for rare liver disease both in neonatal and later ages. In particular, for the early diagnosis of biliary atresia and Wilson’s disease, this center promotes awareness campaigns to diagnose these diseases in a pre-symptomatic phase. A broad spectrum of rare liver diseases (biliary atresia, Alagille syndrome, other genetic cholestasis, autoimmune liver disease, Wilson’s disease, Crigler-Najjar syndromes) are diagnosed and managed in this centre, both in pediatric age and subsequently, with an approach that is centered on the patient and his family.